Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.

doi:10.1016/j.psyneuen.2006.11.003

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Article

Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.

Psychoneuroendocrinology - 1 Feb 2007

Dardennes Roland M, Zizzari Philippe, Tolle Virginie, Foulon Christine, Kipman Amélie, Romo Lucia, Iancu-Gontard Dana, Boni Claudette, Sinet Pierre-Marie, Thérèse Bluet Marie, Estour Bruno, Mouren Marie-Christine, Guelfi Julien-Daniel, Rouillon Frédéric, Gorwood Philip, Epelbaum Jacques

Abstract excerpt

Anorexia nervosa (AN) affects 0.3% of young girls with a mortality of 6%/decade and is strongly familial with genetic factors. Ghrelin is an upstream regulator of the orexigenic peptides NPY and AgRP and acts as a natural antagonist to leptin's effects on NPY/AgRP-expressing neurons, resulting in an increase in feeding and body weight. Obestatin which counteracts ghrelin action on feeding is derived from the same...

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Identifiers

PMID: 17197106
DOI: 10.1016/j.psyneuen.2006.11.003

Genes

BDNF
AGRP
NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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