Article
American genotype structures decrease dengue virus output from human monocytes and dendritic cells.
Journal of virology - 1 Apr 2003
Cologna Raymond, Rico-Hesse Rebeca
Abstract excerpt
The dengue virus type 2 structures probably involved in human virulence were previously defined by sequencing the complete genome of both American and Southeast (SE) Asian genotype templates in patient serum (K. C. Leitmeyer et al., J. Virol. 73:4738-4747, 1999). We have now evaluated the effects of introducing a mutation in the envelope glycoprotein (E) gene and/or replacement of 5'- and 3'-nontranslated regions...
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