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Article

Dengue virus structural differences that correlate with pathogenesis.

Journal of virology - 1 Jun 1999

Leitmeyer K C, Vaughn D W, Watts D M, Salas R, Villalobos I, de Chacon, Ramos C, Rico-Hesse R

Abstract excerpt

The understanding of dengue virus pathogenesis has been hampered by the lack of in vitro and in vivo models of disease. The study of viral factors involved in the production of severe dengue, dengue hemorrhagic fever (DHF), versus the more common dengue fever (DF), have been limited to indirect clinical and epidemiologic associations. In an effort to identify viral determinants of DHF, we have developed a method...

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Identifiers

PMID: 10233934
DOI: 10.1128/JVI.73.6.4738-4747.1999
PMCID: PMC112516

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