Article
Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.
Molecular cancer research : MCR - 1 Dec 2006
Yan Ying, Lu Yan, Wang Min, Vikis Haris, Yao Ruisheng, Wang Yian, Lubet Ronald A, You Ming
Abstract excerpt
Gefitinib (Iressa, ZD1839) is a potent high-affinity competitive tyrosine kinase inhibitor aimed primarily at epidermal growth factor receptor (EGFR). Inhibitors in this class have recently been approved for clinical use in the treatment of advanced non-small cell lung cancer as monotherapy following failure of chemotherapy. We examined the efficacy of gefitinib on lung tumorigenesis in mouse models using both...
Topics
- Animals
- Antineoplastic Agents
- Chemoprevention
- Disease Models, Animal
- ErbB Receptors
- Female
- Gefitinib
- Gene Expression
- Genes, ras
- Lung Neoplasms
- Mice