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Article

Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Jan 2007

Smith N F, Marsh S, Scott-Horton T J, Hamada A, Mielke S, Mross K, Figg W D, Verweij J, McLeod H L, Sparreboom A

Abstract excerpt

To explore retrospectively the relationships between paclitaxel pharmacokinetics and three known, non-synonymous single-nucleotide polymorphisms (SNPs) in SLCO1B3, the gene encoding organic anion transporting polypeptide (OATP)1B3. Accumulation of [(3)H]paclitaxel was studied in Xenopus laevis oocytes injected with cRNA of Oatp1b2, OATP1A2, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, and NTCP. The 334T>G (Ser112Ala),...

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Identifiers

PMID: 17186002
DOI: 10.1038/sj.clpt.6100011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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