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Methylene blue but not indigo carmine causes DNA damage to colonocytes in vitro and in vivo at concentrations used in clinical chromoendoscopy

15 Dec 2006

Abstract excerpt

Identification of mucosal abnormalities is aided by the use of dyes during colonoscopy (chromoendoscopy).1 Two dyes that have found particular favour are methylene blue and indigo carmine.2,3 Methylene blue, which, unlike indigo carmine, is taken up by cells, induces cellular DNA damage in vitro via the generation of singlet oxygen when photoexcited by white light.4 In contrast, indigo carmine appears to be...

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PMID: 17172595
DOI: 10.1136/gut.2006.107300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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