Article
Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG.
Cellular & molecular biology letters - 1 Jan 2006
Arabski Michał, Kazmierczak Paweł, Wiśniewska-Jarosińska Maria, Morawiec Zbigniew, Morawiec-Bajda Alina, Klupińska Grazyna, Drzewoski Józef, Chojnacki Jan, Błasiak Janusz
Abstract excerpt
The pathogenesis of stomach cells can be associated with their susceptibility to exogenous dietary irritants, like nitrosamines such as dimethylnitrosamines (DMNA), and to the effects of non-dietary factors, including Helicobacter pylori infection. We used N-methyl-N'-nitro N-nitrosoguanidyne (MNNG) as a surrogate agent that induces a spectrum of DNA damage similar to DMNA. Using the alkaline comet assay, we...
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