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Article

Clade-specific differences between human immunodeficiency virus type 1 clades B and C: diversity and correlations in C3-V4 regions of gp120.

Journal of virology - 1 May 2007

Gnanakaran S, Lang Dorothy, Daniels Marcus, Bhattacharya Tanmoy, Derdeyn Cynthia A, Korber Bette

Abstract excerpt

Current knowledge of human immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on studies of clade B viruses. We present evidence of sequence and structural differences in viral glycoprotein gp120 between clades B and C. In clade C, the C3 region alpha2-helix exhibits high sequence entropy at the polar face but maintains its amphipathicity, whereas in clade B it accommodates...

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Identifiers

PMID: 17166900
DOI: 10.1128/JVI.01954-06
PMCID: PMC1900169

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