Article
Zincergic innervation of the forebrain distinguishes epilepsy-prone from epilepsy-resistant rat strains.
Neuroscience - 23 Feb 2007
Flynn C, Brown C E, Galasso S L, McIntyre D C, Teskey G Campbell, Dyck R H
Abstract excerpt
Zinc is released from a subset of cerebral cortical neurons whereupon it exerts a powerful modulatory influence on excitatory and inhibitory neurotransmission. A number of studies have suggested that alterations in the regulation of zinc may contribute to the genesis of epilepsy. Here, we tested this hypothesis by examining the distribution of zinc-containing axon terminals in rats selectively bred for an innate...
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