Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

The American journal of pathology - 1 Sept 1991

Lemire J M, Shiojiri N, Fausto N

Abstract excerpt

Oval cells may function as facultative liver stem cells and tumor progenitors in liver carcinogenesis. The authors determined whether oval cells proliferate and if small hepatocytes might be generated from epithelial cell progenitors in noncarcinogenic liver injury. The authors found that oval cells similar to those detected in early carcinogenesis proliferate in response to D-galactosamine (GaIN). Oval cells...

Topics

Animals
Bile Ducts
Binding Sites
Biomarkers
Cell Division
Chemical and Drug Induced Liver Injury
Galactosamine
Immunohistochemistry
Lectins
Liver
Liver Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Nucleic Acid Hybridization

Peanut Agglutinin

Phenotype

Rats

Rats, Inbred F344

Rats, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 1716045
PMCID: PMC1886213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1716045-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.PMID 1716045Read ↗

Cell Lineages in Hepatic Development and the Identification of Progenitor Cells in Normal and Injured LiverSemantic proximity Read ↗

Pluripotential liver stem cells: facultative stem cells located in the biliary treeSemantic proximity Read ↗

Wound healing in the liver with particular reference to stem cellsSemantic proximity Read ↗

Differentiation processes of oval cells into hepatocytes: proposals based on morphological and phenotypical traits in carcinogen-treated hamster liver.Semantic proximity Read ↗

Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats.Semantic proximity Read ↗

The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells.Semantic proximity Read ↗

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.Semantic proximity Read ↗

Generation of hepatocytes from oval cell precursors in culture.Semantic proximity Read ↗

Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response.Semantic proximity Read ↗

Epithelial colonies cultured from human explanted liver in subacute hepatic failure exhibit hepatocyte, biliary epithelial, and stem cell phenotypic markers.Semantic proximity Read ↗

Phenotype and differentiation patterns of the oval cell lines OC/CDE 6 and OC/CDE 22 derived from the livers of carcinogen-treated rats.Semantic proximity Read ↗

Putative liver progenitor cells: conditions for long-term survival in culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.