Article
HLA epitopes detected by serology.
Clinical transplants - 1 Jan 1990
Park M S, Barbetti A A, Geer L I, Clark B D, Terasaki P I, Aoki J
Abstract excerpt
There is evidence that many of the so-called multispecific cytotoxic antisera react to the amino acid-defined epitopes of the HLA-A and B loci molecules. This evidence is based on the finding that a group of sera produced allelic reactions which corresponded to amino acid substitutions. Antisera for 29 amino acid variants were identified at 67 variable residues on the A locus and for 17 of the 51 variable sites...
Topics
- Alleles
- Amino Acid Sequence
- Epitopes
- Genetic Variation
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Immune Sera
- Pattern Recognition, Automated
- Protein Conformation
- Serology