Article
Expression of regulatory T-lymphocyte phenotype in human fetal hemopoietic and lymphoid cell culture.
Bulletin of experimental biology and medicine - 1 Apr 2006
Sharova N I, Donetskova A D, Dubrovina I V, Sukhikh G T, Yarilin A A
Abstract excerpt
Cells with regulatory T-cell phenotype (Treg, CD4+CD25(hi)) were not detected in human fetal thymus, liver, bone marrow, spleen, and among blood mononuclears of 14-28-week gestation. The cells of the majority of these fetal thymuses express Treg specific marker (FOXP3 transcription marker) gene. Culturing of fetal liver and bone marrow cells on a monolayer of thymic epithelial cells induced expression of FOXP3...
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