Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.

doi:10.1016/j.humimm.2014.10.016

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Article

Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.

Human immunology - 1 Jan 2015

Rueda Cesar M, Wells Casey B, Gisslen Tate, Jobe Alan H, Kallapur Suhas G, Chougnet Claire A

Abstract excerpt

Regulatory T-cells (Treg) have a protective role for the control of immune activation and tissue damage. The effects of chorioamnionitis (chorio) on Treg in moderate/late preterm newborns are not known. We hypothesized that infants exposed to chorio would have decreased Treg frequency and/or function. We isolated mononuclear cells from adult peripheral blood and cord blood from term and moderate/late preterm...

Topics

Adult
Antigens, CD
Apyrase
Cell Separation
Chorioamnionitis
Female
Fetal Blood
Gene Expression
HLA-DR Antigens
Humans
Infant, Newborn
Infant, Premature
Ki-67 Antigen
Leukocyte Common Antigens
Lymphocyte Activation

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PMID: 25451985
DOI: 10.1016/j.humimm.2014.10.016
PMCID: PMC4282957

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Pregnancy

Primary Cell Culture