Article
Role of extracellular and intracellular nitric oxide in the regulation of macrophage responses.
Bulletin of experimental biology and medicine - 1 Apr 2006
Malysheva E V, Kruglov S V, Khomenko I P, Bakhtina L Yu, Pshennikova M G, Manukhina E B, Malyshev I Yu
Abstract excerpt
We studied the role of nitric oxide in the stress response and apoptosis. Intracellular nitric oxide potentiated the stress response. However, intracellular nitric oxide suppressed the stress response in macrophages of proinflammatory and antiinflammatory phenotypes. Intracellular nitric oxide promoted apoptosis in macrophages of the proinflammatory phenotype, but inhibited this process in cells of the...
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