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Article

Environmental oxygen tension affects phenotype in cultured bone marrow-derived macrophages.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2004

Pfau Jean C, Schneider Jordan C, Archer Amy J, Sentissi Jami, Leyva Francisco J, Cramton Jennifer

Abstract excerpt

This study tested the hypothesis that the unique phenotype of alveolar macrophages (AM) is maintained through adaptation to the relatively high oxygen partial pressure (P(O2)) of the lung, through modification of redox-sensitive transcription factors. BALB/c mouse bone marrow-derived macrophages (BMC) were differentiated under different P(O2) and compared functionally to AM and peritoneal macrophages (PM). BMC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14527932
DOI: 10.1152/ajplung.00380.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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