Article
What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics.
Archives of general psychiatry - 1 Dec 2006
Schulze Thomas G, Hedeker Donald, Zandi Peter, Rietschel Marcella, McMahon Francis J
Abstract excerpt
CONTEXT: Current diagnostic criteria for bipolar affective disorder define a phenotype that is highly heritable, yet clinically variable. A more homogeneous definition might facilitate genetic and other studies, but the best approach is unclear. Familial features of bipolar disorder should help define more homogeneous subtypes, but there are few data indicating which clinical features of bipolar disorder are the...
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