Article
A single Na(+) channel mutation causing both long-QT and Brugada syndromes.
Circulation research - 1 Jan 2000
Bezzina C, Veldkamp M W, van Den Berg M P, Postma A V, Rook M B, Viersma J W, van Langen I M, Tan-Sindhunata G, Bink-Boelkens M T, van Der Hout A H, Mannens M M, Wilde A A
Abstract excerpt
Mutations in SCN5A, the gene encoding the cardiac Na(+) channel, have been identified in 2 distinct diseases associated with sudden death: one form of the long-QT syndrome (LQT(3)) and the Brugada syndrome. We have screened SCN5A in a large 8-generation kindred characterized by a high incidence of nocturnal sudden death, and QT-interval prolongation and the "Brugada ECG" occurring in the same subjects. An...
Topics
- Adult
- Death, Sudden, Cardiac
- Electrocardiography
- Female
- Humans
- Long QT Syndrome
- Male
- Mutation
- Pedigree
- Sodium Channels