Article
Gene dosage and mutational analyses of EGFR in oligodendrogliomas.
International journal of oncology - 1 Jan 2007
Franco-Hernandez Carmen, Martinez-Glez Victor, Alonso M Eva, De Campos Jose M, Isla Alberto, Vaquero Jesus, Gutierrez Manuel, Rey Juan A
Abstract excerpt
We have studied amplification/gene-dosage and sequence variations of the EGFR gene in 41 oligodendroglial tumours graded according to the WHO classification (21 oligodendrogliomas grade II, 13 oligodendrogliomas grade III and 6 oligoastrocytomas grade II-III), using multiplex ligation-dependent probe amplification (MLPA), real-time quantitative PCR, and PCR/SSCP techniques. To determine gene-dose we studied exons...
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