Article
Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa.
Vaccine - 6 Dec 2004
Wagner Victoria E, Gillis Richard J, Iglewski Barbara H
Abstract excerpt
The opportunistic pathogen Pseudomonas aeruginosa possesses two well-studied quorum-sensing (QS) systems (las and rhl) that are important in the production of virulence factors, antibiotic sensitivity, and biofilm development. High-density oligonucleotide microarrays were used to further characterize the las QS system and to investigate the effect of environment (planktonic or biofilm mode of growth, absence or...
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