Article
Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus.
Clinical chemistry - 1 Jan 2005
Stephens Jeffrey W, Sozen M Mert, Whittall Ros A, Caslake Muriel J, Bedford Dorothy, Acharya Jayshree, Hurel Steven J, Humphries Steve E
Abstract excerpt
BACKGROUND: Apolipoprotein E (apoE) is found in association with triglyceride-rich lipoproteins and is the ligand for the removal of these particles from the plasma. Genetic variations in exon 4 lead to three common gene variants: E2, E3, and E4. METHODS: We performed apoE genotyping in 765 individuals with type 2 diabetes. RESULTS: We identified three new variant heteroduplex patterns. Sequencing of these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.