Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP.

doi:10.1038/bjc.1991.237

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Article

Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP.

British journal of cancer - 1 Jul 1991

Wolf D A, Schulz P, Fittler F

Abstract excerpt

Experiments have been designed to investigate hormonal effects on the human prostatic carcinoma cell line LNCaP in the presence of complete foetal calf serum. At physiological concentrations (3.3 x 10(-9)M), several derivatives of 17 alpha-methyl-testosterone led to a significant reduction of cel...

Topics

Antigens, Neoplasm
Cell Aggregation
Cell Division
Cell Line
Dihydrotestosterone
Genes, myc
Humans
Male
Phenotype
Prostate-Specific Antigen
Prostatic Neoplasms
RNA, Messenger
Testosterone Congeners

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