Article
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.
Nature reviews. Cancer - 1 Dec 2006
Toledo Franck, Wahl Geoffrey M
Abstract excerpt
Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also known as MDMX) downregulate p53 function in many of the rest. Understanding p53 regulation remains a crucial goal to design broadly applicable anticancer strategies based on this pathway. This Review of in vitro studies, human tumour data and...
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