Article
[Beta-myosin heavy-chain gene mutations in patients with hypertrophic cardiomyopathy].
Revista espanola de cardiologia - 1 Oct 2006
Laredo Rafael, Monserrat Lorenzo, Hermida-Prieto Manuel, Fernández Xusto, Rodríguez Isabel, Cazón Laura, Alvariño Inés, Dumont Carlos, Piñón Pablo, Peteiro Jesús, Bouzas Beatriz, Castro-Beiras Alfonso
Abstract excerpt
INTRODUCTION AND OBJECTIVES: To determine the frequency of mutations in the beta-myosin heavy-chain gene (MYH7) in a cohort of patients with hypertrophic cardiomyopathy (HCM) and their families, and to investigate correlations between genotype and phenotype. METHODS: Single-strand conformation polymorphism analysis and sequencing of fragments with abnormal MYH7 gene mobility were carried out in 128 consecutive...
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