Article
Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) - 1 Jun 2005
Perrot Andreas, Schmidt-Traub Hajo, Hoffmann Bernard, Prager Matthias, Bit-Avragim Nana, Rudenko Raisa I, Usupbaeva Dinara A, Kabaeva Zhyldyz, Imanov Bakytbek, Mirrakhimov Mirsaid M, Dietz Rainer, Wycisk Anna, Tendera Michal, Gessner Reinhard, Osterziel Karl Josef
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a frequent, autosomal-dominant cardiac disease and manifests predominantly as left ventricular hypertrophy. Mutations in the cardiac beta-myosin heavy chain gene (MYH7) are responsible for the disease in about 30% of cases where mutations were identified. We clinically evaluated a large group of 147 consecutive HCM patients from three cardiology centers in Germany, Poland, and...
Topics
- Adolescent
- Adult
- Aged
- Amino Acid Sequence
- Cardiac Myosins
- Cardiomyopathy, Hypertrophic
- Child
- DNA Mutational Analysis
- Female
- Genotype