Article
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Journal of negative results in biomedicine - 24 Nov 2006
Freathy Rachel M, Mitchell Simon M S, Knight Beatrice, Shields Beverley, Weedon Michael N, Hattersley Andrew T, Frayling Timothy M
Abstract excerpt
BACKGROUND: Reduced growth during infancy is associated with adult insulin resistance. In a UK Caucasian cohort, the CSH1.01 microsatellite polymorphism in the growth hormone-chorionic somatomammotropin hormone gene cluster was recently associated with increases in adult fasting insulin of approximately 23 pmol/l for TT homozygote males compared to D1D1 or D2D2 homozygotes (P = 0.001 and 0.009; n = 206 and 92,...
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