Article
Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence.
The Journal of clinical endocrinology and metabolism - 1 Dec 2001
Ibáñez L, Ong K, Potau N, Marcos M V, de Zegher F, Dunger D
Abstract excerpt
Low birth weight associations with hyperinsulinemia and other adulthood disease risk factors have been described in several cohorts, including girls who present with precocious pubarche (pubic hair <8 yr). We hypothesized that these associations might be influenced by the insulin gene (INS) variable number of tandem repeat (VNTR), a common polymorphism related to INS transcription levels. In 141 Caucasian girls,...
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