Monoclonal antibodies define linear and conformational epitopes of HIV-1 pol gene products.

doi:10.1089/aid.1991.7.307

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Article

Monoclonal antibodies define linear and conformational epitopes of HIV-1 pol gene products.

AIDS research and human retroviruses - 1 Mar 1991

Ferns R B, Partridge J C, Tisdale M, Hunt N, Tedder R S

Abstract excerpt

Purified recombinant reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1) was used to raise 21 monoclonal antibodies with anti-RT specificities. The antibodies were characterized using Western blotting against native virus and recognized either the p66 or p66, p51 components of RT. Further immunoblotting using either cyanogen bromide fragmented RT or truncated mutants of RT along with...

Topics

Animals
Antibodies, Monoclonal
Binding, Competitive
Blotting, Western
Cyanogen Bromide
Endoribonucleases
Enzyme-Linked Immunosorbent Assay
Epitopes
Female
HIV Antibodies
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Neutralization Tests

Protein Conformation

RNA-Directed DNA Polymerase

Ribonuclease H

Source

Open in PubMed

Identifiers

PMID: 1712217
DOI: 10.1089/aid.1991.7.307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1712217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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