Article
Monoclonal antibodies to the extracellular domain of HIV-1IIIB gp160 that neutralize infectivity, block binding to CD4, and react with diverse isolates.
AIDS research and human retroviruses - 1 Nov 1992
Nakamura G R, Byrn R, Rosenthal K, Porter J P, Hobbs M R, Riddle L, Eastman D J, Dowbenko D, Gregory T, Fendly B M
Abstract excerpt
Ten monoclonal antibodies prepared against a soluble, recombinant form of gp160, derived from the IIIB isolate of HIV-1, were characterized. Four of the antibodies neutralized HIV-1IIIB infectivity in vitro, three blocked the binding of recombinant gp120 to CD4, three were reactive with gp41, and one preferentially reacted with an epitope on gp120 within the gp160 precursor. All three CD4 blocking antibodies...
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