Article
Monoclonal antibodies to the extracellular domain of HIV-1IIIB gp160 that neutralize infectivity, block binding to CD4, and react with diverse isolates.
AIDS research and human retroviruses - 1 Nov 1992
Nakamura G R, Byrn R, Rosenthal K, Porter J P, Hobbs M R, Riddle L, Eastman D J, Dowbenko D, Gregory T, Fendly B M
Abstract excerpt
Ten monoclonal antibodies prepared against a soluble, recombinant form of gp160, derived from the IIIB isolate of HIV-1, were characterized. Four of the antibodies neutralized HIV-1IIIB infectivity in vitro, three blocked the binding of recombinant gp120 to CD4, three were reactive with gp41, and...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- CD4 Antigens
- CHO Cells
- Cricetinae
- Cross Reactions
- Epitopes
- Gene Products, env
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Envelope Protein gp160
- Neutralization Tests
- Protein Conformation