Article
Haplotypes of surfactant protein C are associated with common paediatric lung diseases.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Dec 2006
Puthothu Beena, Krueger Marcus, Heinze Jessica, Forster Johannes, Heinzmann Andrea
Abstract excerpt
Surfactant protein C is part of the surfactant complex lining up the alveoles and thereby inhibiting collapse of the airways. In addition it is involved in innate immune responses. Rare polymorphisms within surfactant protein C have been linked to sporadic paediatric lung diseases, like proteinosis or interstitial lung diseases. One study in the Finnish population described association of common polymorphisms...
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