Article
Major acute-phase reactant synthesis during chronic inflammation in amyloid-susceptible and -resistant mouse strains.
Inflammation - 1 Feb 1991
Zahedi K, Gonnerman W A, Debeer F C, Debeer M C, Steel D M, Sipe J D, Whitehead A S
Abstract excerpt
Hepatic levels of mRNA specific for total serum amyloid A (SAA), the SAA1 and SAA2 isotypes, serum amyloid P (SAP), C-reactive protein (CRP), and fibronectin, as well as the plasma concentrations of SAA and SAP were examined in amyloid-resistant (A/J) and amyloid-susceptible (CBA/J) mice during azocasein-induced chronic inflammation. In both strains hepatic SAA and SAP mRNA levels and plasma SAA and SAP protein...
Topics
- Acute-Phase Proteins
- Amyloidosis
- Animals
- Caseins
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Inflammation
- Liver
- Mice
- Mice, Inbred A