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Article

An HLA-A2.1-Transgenic Rabbit Model to Study Immunity to Papillomavirus Infection

1 Dec 2006

Abstract excerpt

We have established several HLA-A2.1-transgenic rabbit lines to provide a host to study CD8(+) T cell responses during virus infections. HLA-A2.1 protein expression was detected on cell surfaces within various organ tissues. Continuous cultured cells from these transgenic rabbits were capable of presenting both endogenous and exogenous HLA-A2.1-restricted epitopes to an HLA-A2.1-restricted epitope-specific CTL...

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PMID: 17114477
DOI: 10.4049/jimmunol.177.11.8037

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