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Article

DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.

Schizophrenia research - 1 Feb 2007

Xu Haiyan, Kellendonk Christoph B, Simpson Eleanor H, Keilp John G, Bruder Gerard E, Polan H Jonathan, Kandel Eric R, Gilliam T Conrad

Abstract excerpt

The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory performance in 188...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17113268
DOI: 10.1016/j.schres.2006.10.001

Genes

COMT
DRD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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