Article
Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991
Kavanaugh A F, Lightfoot E, Lipsky P E, Oppenheimer-Marks N
Abstract excerpt
The role of leukocyte function-associated Ag-1 (LFA-1) (CD11a/CD18) in T cell-endothelial cell (EC) interactions was assessed by utilizing CD11a/CD18-deficient T cell clones generated from a patient with leukocyte adhesion deficiency (LAD). The ability of these clones to bind to and migrate through monolayers of EC in vitro was compared with that of clones generated in a similar manner from normal controls. The...
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