Article
Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991
Kavanaugh A F, Lightfoot E, Lipsky P E, Oppenheimer-Marks N
Abstract excerpt
The role of leukocyte function-associated Ag-1 (LFA-1) (CD11a/CD18) in T cell-endothelial cell (EC) interactions was assessed by utilizing CD11a/CD18-deficient T cell clones generated from a patient with leukocyte adhesion deficiency (LAD). The ability of these clones to bind to and migrate throu...
Topics
- Antibodies, Monoclonal
- Antigens, CD
- CD11 Antigens
- CD18 Antigens
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Clone Cells
- Endothelium, Vascular
- Humans
- Intercellular Adhesion Molecule-1
- Interleukin-1
- Phenotype
- Receptors, Very Late Antigen
- T-Lymphocytes
- Vascular Cell Adhesion Molecule-1