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Article

Cross-linking of LFA-1 induces secretion of macrophage inflammatory protein (MIP)-lalpha and MIP-1beta with consequent directed migration of activated lymphocytes.

European journal of immunology - 1 Oct 2000

Murphy A, Long A, Volkov Y, Kelleher D

Abstract excerpt

Cross-linking of LFA-1 induces an active locomotory phenotype in T cells. In this study we demonstrate that cross-linking of LFA-1 using a monoclonal antibody results in the secretion of MIP-1alpha and MIP-1beta. Similar results were seen with anti-CD44 but not with anti-transferrin receptor or anti-MHC class 1. We examined the ability of activated lymphocytes to migrate onto a substrate consisting of large...

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Source

Identifiers

PMID: 11069084
DOI: 10.1002/1521-4141(200010)30:10<3006::AID-IMMU3006>3.0.CO;2-4

Genes

MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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