Article
Cross-linking of LFA-1 induces secretion of macrophage inflammatory protein (MIP)-lalpha and MIP-1beta with consequent directed migration of activated lymphocytes.
European journal of immunology - 1 Oct 2000
Murphy A, Long A, Volkov Y, Kelleher D
Abstract excerpt
Cross-linking of LFA-1 induces an active locomotory phenotype in T cells. In this study we demonstrate that cross-linking of LFA-1 using a monoclonal antibody results in the secretion of MIP-1alpha and MIP-1beta. Similar results were seen with anti-CD44 but not with anti-transferrin receptor or anti-MHC class 1. We examined the ability of activated lymphocytes to migrate onto a substrate consisting of large...
Topics
- Antibodies, Monoclonal
- Chemokine CCL3
- Chemokine CCL4
- Chemotaxis, Leukocyte
- Cytoskeleton
- HLA Antigens
- Humans
- Hyaluronan Receptors
- Isoenzymes
- Lymphocyte Activation
- Lymphocyte Function-Associated Antigen-1