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Article

Molecular characterization of leukocyte adhesion deficiency in six patients.

European journal of immunology - 1 Mar 1995

Wright A H, Douglass W A, Taylor G M, Lau Y L, Higgins D, Davies K A, Law S K

Abstract excerpt

Leukocyte adhesion deficiency (LAD) is caused by defects in the CD18 gene, which codes for the common beta 2 subunit of the leukocyte integrins LFA-1, Mac-1 and p150,95. Failure to produce a functional beta 2 subunit results in the defective expression of all three leukocyte integrins, and the leukocytes of LAD patients have subnormal adhesion properties. Six patients with LAD were studied. Patient B was...

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Identifiers

PMID: 7705401
DOI: 10.1002/eji.1830250313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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