Molecular characterization of leukocyte adhesion deficiency in six patients.

doi:10.1002/eji.1830250313

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Article

Molecular characterization of leukocyte adhesion deficiency in six patients.

European journal of immunology - 1 Mar 1995

Wright A H, Douglass W A, Taylor G M, Lau Y L, Higgins D, Davies K A, Law S K

Abstract excerpt

Leukocyte adhesion deficiency (LAD) is caused by defects in the CD18 gene, which codes for the common beta 2 subunit of the leukocyte integrins LFA-1, Mac-1 and p150,95. Failure to produce a functional beta 2 subunit results in the defective expression of all three leukocyte integrins, and the le...

Topics

Alleles
Base Sequence
CD18 Antigens
DNA, Complementary
Flow Cytometry
Humans
Leukocyte-Adhesion Deficiency Syndrome
Lymphocyte Function-Associated Antigen-1
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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