Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways.

doi:10.1530/ERC-12-0183

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Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways.

Endocrine-related cancer - 1 Aug 2013

de Cubas Aguirre A, Leandro-García L Javier, Schiavi Francesca, Mancikova Veronika, Comino-Méndez Iñaki, Inglada-Pérez Lucía, Perez-Martinez Manuel, Ibarz Nuria, Ximénez-Embún Pilar, López-Jiménez Elena, Maliszewska Agnieszka, Letón Rocío, Gómez Graña Alvaro, Bernal Carmen, Alvarez-Escolá Cristina, Rodríguez-Antona Cristina, Opocher Giuseppe, Muñoz Javier, Megias Diego, Cascón Alberto, Robledo Mercedes

Abstract excerpt

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasias of neural crest origin that can be part of several inherited syndromes. Although their mRNA profiles are known to depend on genetic background, a number of questions related to tumor biology and clinical behavior remain unanswered. As microRNAs (miRNAs) are key players in the modulation of gene expression, their comprehensive...

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PMID: 23660872
DOI: 10.1530/ERC-12-0183

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