Article
Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients.
European journal of dermatology : EJD - 1 Jan 2000
Biral A C, Magalhaes R F, Wastowski I J, Simoes R, Donadi E A, Simoes A L, Mendes-Junior C T, Tanaka A M, Kraemer M H S
Abstract excerpt
This study investigated the genetic association of HLA class I genes and TNF-alpha microsatellites. HLA-A, -B, -C typing was carried out in 92 psoriasis vulgaris patients and 160 healthy individuals using a PCR-SSP method. 70 patients and 71 controls were typed for five microsatellite polymorphisms, TNFa-e. HLA-B*13 Cw*06, HLA-B*57 Cw*06 and HLA-B*39 Cw*12 haplotypes were found to be increased in patients with...
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