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Article

Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.

Journal of virology - 1 Feb 2007

Tusell Sonia M, Schittone Stephanie A, Holmes Kathryn V

Abstract excerpt

Feline coronavirus (FCoV), porcine transmissible gastroenteritis coronavirus (TGEV), canine coronavirus (CCoV), and human coronavirus HCoV-229E, which belong to the group 1 coronavirus, use aminopeptidase N (APN) of their natural host and feline APN (fAPN) as receptors. Using mouse-feline APN chimeras, we identified three small, discontinuous regions, amino acids (aa) 288 to 290, aa 732 to 746 (called R1), and aa...

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Identifiers

PMID: 17093189
DOI: 10.1128/JVI.01510-06
PMCID: PMC1797531

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Source receipt: pubmed, retrieved 7 Sept 2026.

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