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Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus

19 Mar 2015

Abstract excerpt

Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV,...

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PMID: 25787280
DOI: 10.1128/jvi.00430-15

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