Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats.

doi:10.1016/0303-7207(91)90161-k

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Article

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats.

Molecular and cellular endocrinology - 1 Mar 1991

Cawthorn E G, Chan C B

Abstract excerpt

We used isolated islets of lean and obese Zucker rats to determine whether inhibitory pathways mediated by pertussis toxin-sensitive guanyl nucleotide-binding (Gi) proteins contribute to hyperinsulinemia in obese rats. Epinephrine (10(-4) M) and somatostatin (10(-7) M) inhibited insulin secretion...

Topics

1-Methyl-3-isobutylxanthine
Animals
Cyclic AMP
Epinephrine
Female
GTP-Binding Proteins
Galanin
Glucose
Insulin
Insulin Secretion
Islets of Langerhans
Obesity
Peptides
Pertussis Toxin
Phenotype
Rats
Rats, Zucker
Somatostatin

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