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Article

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats.

Molecular and cellular endocrinology - 1 Mar 1991

Cawthorn E G, Chan C B

Abstract excerpt

We used isolated islets of lean and obese Zucker rats to determine whether inhibitory pathways mediated by pertussis toxin-sensitive guanyl nucleotide-binding (Gi) proteins contribute to hyperinsulinemia in obese rats. Epinephrine (10(-4) M) and somatostatin (10(-7) M) inhibited insulin secretion by +/- 75% in lean and fa/fa rats. Overnight culture of islets with pertussis toxin (300 ng/ml) enhanced insulin...

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Identifiers

PMID: 1709122
DOI: 10.1016/0303-7207(91)90161-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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