Developmental regulation of amylin and insulin-gene expression in lean (Fa/Fa) and obese (fa/fa) Zucker rats.

doi:10.2337/diab.41.6.685

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Developmental regulation of amylin and insulin-gene expression in lean (Fa/Fa) and obese (fa/fa) Zucker rats.

Diabetes - 1 Jun 1992

Koranyi L, Tanizawa Y, Penicaud L, Atef N, Girard J, Permutt M A

Abstract excerpt

Obese individuals are hyperinsulinemic and insulin resistant. Because amylin is cosecreted with insulin and may contribute to the insulin resistance of obesity, this study tested the hypothesis that insulin and amylin genes are coordinately regulated by obesity and carbohydrate feeding. Insulin and amylin gene expression were measured during the suckling/weaning transition in lean (Fa/Fa) and obese (fa/fa) Zucker...

Topics

Aging
Amyloid
Animals
Blood Glucose
DNA
DNA Probes
Gene Expression Regulation
Genotype
Insulin
Islet Amyloid Polypeptide
Islets of Langerhans
Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreas

RNA

RNA Probes

RNA, Messenger

Rats

Rats, Zucker

Source

Open in PubMed

Identifiers

PMID: 1375176
DOI: 10.2337/diab.41.6.685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1375176-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Developmental regulation of amylin and insulin-gene expression in lean (Fa/Fa) and obese (fa/fa) Zucker rats.PMID 1375176Read ↗

Acute injection of beta-adrenoceptor agonist BRL 35135 corrects both impaired uncoupling protein and lipoprotein lipase gene expression but not hypercapacity of lipogenesis in brown adipose tissue of suckling fa/fa rats.Semantic proximity Read ↗

Differential polypeptide expression in adipose tissue of lean and obese Zucker rats. Evidence of specifically repressed peptides in 7-day-old pre-obese rats.Semantic proximity Read ↗

Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat.Semantic proximity Read ↗

Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats.Semantic proximity Read ↗

Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats.Semantic proximity Read ↗

Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day 12.Semantic proximity Read ↗

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats.Semantic proximity Read ↗

Adrenalectomy in the Zucker fatty rat: effect on m-RNA for malic enzyme and glyceraldehyde 3-phosphate dehydrogenase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.