Article
Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent.
Journal of bacteriology - 1 Feb 2007
Hendriksen Wouter T, Silva Nuno, Bootsma Hester J, Blue Clare E, Paterson Gavin K, Kerr Alison R, de Jong Anne, Kuipers Oscar P, Hermans Peter W M, Mitchell Tim J
Abstract excerpt
Recent murine studies have demonstrated that the role of response regulator 09 (RR09) of Streptococcus pneumoniae in virulence is different in different strains. In the present study, we used a murine pneumonia model of infection to assess the virulence of a TIGR4 rr09 mutant, and we found that TIGR4Deltarr09 was attenuated after intranasal infection. Furthermore, we investigated the in vitro transcriptional...
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