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Article

Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Dec 2006

Jack Dominic L, Cole Joby, Naylor Simone C, Borrow Raymond, Kaczmarski Edward B, Klein Nigel J, Read Robert C

Abstract excerpt

BACKGROUND: Meningococcal disease occurs after colonization of the nasopharynx with Neisseria meningitidis. Surfactant protein (SP)-A and SP-D are pattern-recognition molecules of the respiratory tract that activate inflammatory and phagocytic defences after binding to microbial sugars. Variation in the genes of the surfactant proteins affects the expression and function of these molecules. METHODS: Allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17083016
DOI: 10.1086/508775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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