Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection.

doi:10.1186/cc13934

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Article

Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection.

Critical care (London, England) - 20 Jun 2014

Herrera-Ramos Estefanía, López-Rodríguez Marta, Ruíz-Hernández José Juan, Horcajada Juan Pablo, Borderías Luis, Lerma Elisabeth, Blanquer José, Pérez-González María Carmen, García-Laorden María Isabel, Florido Yanira, Mas-Bosch Virginia, Montero Milagro, Ferrer José María, Sorlí Luisa, Vilaplana Carlos, Rajas Olga, Briones Marisa, Aspa Javier, López-Granados Eduardo, Solé-Violán Jordi, de Castro Felipe Rodríguez, Rodríguez-Gallego Carlos

Abstract excerpt

INTRODUCTION: Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components of the innate immune response may be crucial in the first days of the infection. The collectins surfactant protein (SP)-A1, -A2, and -D and mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can...

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Identifiers

PMID: 24950659
DOI: 10.1186/cc13934
PMCID: PMC4229788

Genes

SFTPA2
MBL2
SFTPA1
SFTPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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