Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study.

doi:10.1186/cc10030

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Article

Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study.

Critical care (London, England) - 1 Jan 2011

García-Laorden M Isabel, Rodríguez de Castro Felipe, Solé-Violán Jordi, Rajas Olga, Blanquer José, Borderías Luis, Aspa Javier, Briones M Luisa, Saavedra Pedro, Marcos-Ramos J Alberto, González-Quevedo Nereida, Sologuren Ithaisa, Herrera-Ramos Estefanía, Ferrer José M, Rello Jordi, Rodríguez-Gallego Carlos

Abstract excerpt

INTRODUCTION: Genetic variability of the pulmonary surfactant proteins A and D may affect clearance of microorganisms and the extent of the inflammatory response. The genes of these collectins (SFTPA1, SFTPA2 and SFTPD) are located in a cluster at 10q21-24. The objective of this study was to evaluate the existence of linkage disequilibrium (LD) among these genes, and the association of variability at these genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21310059
DOI: 10.1186/cc10030
PMCID: PMC3221990

Genes

SFTPA1
SFTPA2
SFTPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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