A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.

Abstract excerpt

Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eye Abnormalities
• Share to Intracellular Signaling Peptides and Proteins