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Article

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity.

FEBS letters - 19 Nov 2009

Ferreira Nelson, Cardoso Isabel, Domingues Maria Rosário, Vitorino Rui, Bastos Margarida, Bai Guangyue, Saraiva Maria João, Almeida Maria Rosário

Abstract excerpt

More than 100 transthyretin (TTR) variants are associated with hereditary amyloidosis. Approaches for TTR amyloidosis that interfere with any step of the cascade of events leading to fibril formation have therapeutic potential. In this study we tested (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of green tea, as an inhibitor of TTR amyloid formation. We demonstrate that EGCG binds to TTR "in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19861125
DOI: 10.1016/j.febslet.2009.10.062

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity.PMID 19861125Read ↗

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