Elevated TWIST1 expression in myelodysplastic syndromes/acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine

Abstract excerpt

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of myeloid neoplasms characterized by peripheral blood cytopenia, hematopoietic cell dysplasia, and transformation to secondary acute myeloid leukemia (AML) in 30% of cases. 1 Epigenetic changes are recognized as major drivers of MDS progression. A recent study indicates that DNA hypermethylation is a relevant parameter of MDS at the molecular level....

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