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Article

Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo

10 Jan 2025

Abstract excerpt

Background IGFBP5 is a differentially expressed gene (DEG) between M1 and M2 macrophages. This study explained why it causes opposite effects in different circumstances. Methods Gene expression profiles of various cell subsets were compared by mining a public database. THP-1 cells were treated by siRNAs, recombinant IGFBP5, lipopolysaccharide (LPS), picropodophyllin, IGF1 or the combinations. Clinical implication...

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PMID: 39867883
DOI: 10.3389/fimmu.2024.1539317

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