Article
Recent assembly of an imprinted domain from non-imprinted components.
PLoS genetics - 1 Oct 2006
Rapkins Robert W, Hore Tim, Smithwick Megan, Ager Eleanor, Pask Andrew J, Renfree Marilyn B, Kohn Matthias, Hameister Horst, Nicholls Robert D, Deakin Janine E, Graves Jennifer A Marshall
Abstract excerpt
Genomic imprinting, representing parent-specific expression of alleles at a locus, raises many questions about how--and especially why--epigenetic silencing of mammalian genes evolved. We present the first in-depth study of how a human imprinted domain evolved, analyzing a domain containing several imprinted genes that are involved in human disease. Using comparisons of orthologous genes in humans, marsupials,...
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